Ceruloplasmin Test Rate In Delhi @ 850 only

Ceruloplasmin Test (Blood)

What is this examination –

This test determines the concentration of a copper-containing protein in your blood. This test is used to diagnose copper-related issues such as Wilson disease. Wilson disease is a rare inherited disease. It results in an excess of copper in your blood.

Ceruloplasmin is a protein produced by your liver. It stores and transports copper throughout your body. Ceruloplasmin transports 65% to 90% of the copper found in blood. Copper is essential to many bodily processes. These include bone formation and melanin production. However, having too much copper in your body can be toxic.

Copper is not added to ceruloplasmin in Wilson disease. The disease also prevents your liver from excreting excess copper through your bowel movements. Instead, copper accumulates in your liver and overflows into your bloodstream. Copper then accumulates in your brain, corneas, kidneys, liver, bones, and small glands near your thyroid. Wilson disease’s copper poisoning causes liver and brain damage that is fatal if not treated.

If you have Wilson disease, you should avoid eating copper-rich foods. Liver, shellfish, mushrooms, nuts, and chocolate are examples. You should also avoid taking copper-containing dietary supplements. You should also have the copper levels in your drinking water tested.

Why do I require this examination?

If you have a family history of Wilson disease, you may require this test. To have the disease, you must inherit an abnormal gene from both parents. As a result, even without a known family history, this condition is possible. Symptoms usually appear between the ages of 5 and 40. They can, however, appear earlier or later in life.

You may also be subjected to this test if you have nerve or liver problems that resemble hepatitis symptoms.

Copper toxicity in the central nervous system, for example, caused by Wilson disease, can result in:

Having difficulty speaking or swallowing

• Tremors

• Coordination failure

• Muscle spasms

• Behavior Modifications

• Wilson disease’s copper toxicity in the liver can result in:

• Swelling of the liver or spleen

• Skin and eye discoloration (jaundice)

• Fluid accumulation in the legs and abdomen

• Extreme exhaustion

• There’s a lot of bruising.

• Other Wilson disease symptoms include:

• Anemia

• Platelet or white blood cell count is low.

• Slow clotting of the blood

• Urine contains high levels of amino acids, protein, uric acid, and carbohydrates.

• Arthritis and osteoporosis

Kayser-Fleischer rings are another possibility. These are brown rings within the corneas of your eyes. These rings are only visible during an eye exam and are a clear indication of Wilson disease. The rings appear in 95% of people with Wilson disease who have nerve symptoms. They occur in approximately 65% of people with liver symptoms.

What other tests could I have in addition to this one?

You may also be tested for copper levels in your blood, urine, or liver tissue.

Your doctor may also look for:

• Kayser-Fleischer rings in your corneas

• Low copper levels in your blood serum

• A high level of copper in a 24-hour urine sample. This equates to more than 40 micrograms (mcg) per day.

• Higher levels of amino acids in

• Increased amino acid levels in your urine

• Low red cell count, also known as hemolytic anaemia

• Your physician may also prescribe:

• Liver function tests are performed. A liver biopsy is performed to look for damage, disease, and copper levels.

• Genetic analysis

• An MRI scan. You may require this if you are experiencing nerve problems or behavioural changes.

• A CT scan

What do the results of my tests mean?

Your test results may differ depending on your age, gender, medical history, and other factors. Depending on the lab used, your test results may differ. They may not indicate that you have a problem. Inquire with your doctor about the significance of your test results.

In an adult, the normal range for a ceruloplasmin serum test is 20 to 35 milligrammes per deciliter (mg/dL). If you have Wilson disease, your ceruloplasmin level is most likely less than 10 mg/dL.

Low ceruloplasmin levels may also indicate Menkes disease. This is a genetic condition that makes it difficult for your body to absorb copper. Low ceruloplasmin levels may also indicate:

Nephrotic syndrome, also known as kidney problems

End-stage liver disease

Nutrient absorption issues

Because of pregnancy, oestrogen therapy, and birth control pills, your ceruloplasmin level may be higher than normal. A higher ceruloplasmin level can also be caused by diseases such as leukaemia, Hodgkin lymphoma, primary biliary cirrhosis, and rheumatoid arthritis.

The copper level in your blood is usually lower than normal if you have Wilson disease. However, if you also have acute liver failure, it may be higher than normal. Even if you have Wilson disease and acute hepatitis, your ceruloplasmin levels may be normal.

How is this test carried out?

A blood sample is used for the test. Blood is drawn from a vein in your arm or hand using a needle.

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